Design and synthesis by activation of CH bonds of a new family of molecules of biological interest
Design and synthesis by activation of CH bonds of a new family of molecules of biological interest
Over the past five decades, organic chemists have increasingly used transition metal catalysts as precursors for the formation of Carbon-Carbon (CC) bonds. Among the most commonly used reactions are cross-couplings that allow the functionalization of various substrates in ways previously thought impossible. Nowadays, the application of these reactions has become a pillar for the preparation of molecules of biological interest with very complex structures.
Despite the undeniable progress, cross-couplings require two prefunctionalized substrates, which results in lengthy syntheses and also the formation of undesirable by-products. On the other hand, the activation of C–H bonds represents an environmentally friendly and economically attractive strategy for organic syntheses, making it possible to avoid pre-functionalizations and thus reducing the generation of potentially hazardous waste.
In this context, this thesis project aims to explore the activation of CC bonds in aromatic compounds in order to prepare new families of molecules of biological interest.
Eligible candidates must have a master's degree or equivalent (bac + 5) in the field of organic chemistry, molecular chemistry or medicinal chemistry with solid knowledge in analytical chemistry and biology
Registration procedure
- Application file: Curriculum vitae, cover letter, end-of-studies project, diplomas and transcripts
- Working conditions: The doctoral student will carry out full-time research work at the Euromed University of Fez and the University of Orléans
File to be sent to s.elkazzouli@ueuromed.org before September 30, 2023